Francis Spilsbury II was the son of Francis Spilsbury I and was born in 1733.

Free by patrimony, 2nd November 1757. Livery, July 1763. Mark entered as small worker, 24th November 1767. Address: 24 Gutter Lane. Heal records him as a plate worker, 1767 - 73 and he so appears at the same address in the Parl. Report list 1773, when he gave evidence to the committee of the leakage of new designs for the plate at the Assay Office and of corruption in the staff. He found “giving liquor at the Hall” prevented trouble with the assay. He also informed the committee that “he sells his manufactures viz. cruet frames, bottle stands, pails, mustard pots and salts in general to shopkeepers in London and receives old silver for weight of the plate and money for the fashion." He knew of examples of the cutting out of marks but had avoided trouble by not reporting them. He died on 6^th august 1793 “at Hampstead aged 60, Mr Spilsbury of Soho sq. proprietor of the anti-scorbutic drops. He was a silversmith in Noble St. Cheapside and turned quack about 25 years ago when he first kept a shop in Mount Row Lambeth. By his 2^nd wife who survives him he has left a numerous young family" (Gentleman’s Magazine p. 773). Robert Spilsbury goldworker (Section VII) may, perhaps, be connected.